TB

Signs and symptoms

Very variable depending on organs affected. Persistent fever / drenching night sweats; weight loss; failure to thrive; cough; anaemia <8g/dl; enlarged nodes; meningitis signs

Investigations

Clinical exam and history Often difficult to confirm in PLHIV. Clinical diagnosis is critical, particularly in children with possible TB signs/symptoms and TB contact, even if investigations are not clear.

Xpert MTB-RIF 2x sputum Also consider: ascites, CSF, lymph gland material, pleural or pericardial fluid CXR Microscopy Fine needle aspiration of lymph nodes; CSF Biochemistry Pleural tap: straw coloured effusion? CSF Urine LAM See section 8.1on page 22 Focused Assessment with Sonography for HIV associated tuberculosis (FASH)

Test for COVID-19 Primary and secondary management See National TB guidelines