5.1
Risk Groups & Advice
Guidelines for the Treatment of Malaria in Malawi, 6th Edition, 2025. Chapter 5, Selective Antimalarial Chemoprophylaxis.
Clinical description
High-risk groups for chemoprophylaxis
- Patients who have had a splenectomy
- Those taking cytotoxic or immunosuppressive drugs for malignant disease
- Hyper-reactive malarial splenomegaly (previously known as tropical splenomegaly syndrome)
- Children who have had recurrent severe malaria
- Individuals with sickle cell disease
- Visitors from countries where there is no malaria transmission
Treatment
General advice
Emphasize that no prophylaxis is 100% effective. Advise other measures also (especially to sleep under an insecticide-treated bed net every night and to promptly seek care in the event of a fever).
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