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10.7.1

Lymphoma

Malawi Standard Treatment Guidelines, 6th Edition, 2023. Chapter 10, Oncology.

Clinical Description

  • Refer patient to an Oncology Centre after diagnosis is made.
  • If available, refer the patient with current FBC, U +Es and LFT results.
  • Basic staging investigations include CXR and abdominal USS

Pharmacological

Chemotherapy

  • Aggressive lymphomas have a reasonably good response to a combination of chemotherapeutic agents:
  • Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone given once every three weeks (CHOP 21) +/- Rituximab (R-CHOP) for Diffuse Large B-Cell Lymphoma.
  • Before starting patients on Doxorubicin, a cardiac ultrasound is required as

Doxorubicin is cardiotoxic.

  • Intrathecal chemotherapy may be required depending on patient presentation
  • Doxorubicin (Adriamycin), Bleomycin, Vinblastine, Dacarbazine (ABVD) for Hodgkin’s Lymphoma
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