Indications for Fresh Frozenplasma

Clinical Description

• Replacement of single factor deficiencies (if single factor concentrates are not available)
• Immediate reversal of warfarin effect
• Vitamin K deficiency associated with active bleeding
• Acute disseminated intravascular coagulopathy (DIC)
• Thrombotic thrombocytopenic purpura (TTP)
• May be used in massive transfusion or liver disease

Dose:

• 15-20ml/kg

Side effects:

• Acute allergic reactions are common.
• Febrile, non haemolytic reaction
• Viral transmission
• Bacterial contamination – sepsis

No justification for use in hypovolemia, nutritional support in protein losing states or/and plasma exchange except in TTP. FFP transfusion does not require group and crossmatching.