Aspirin Use In Pregnancy

Clinical description

Aspirin therapy is used for thromboprophylaxis in the reproductive-aged woman andfor preeclampsia prophylaxis in the obstetric patient.

With regard to obstetrics, 2meta-analyses found 13-15% reduction in preeclampsia especially for high riskwomen, 8% reduction in preterm delivery (PTD), and 14% reduction in fetal orneonatal death.

Diagnosis History/Exam/Investigations Evaluate for indications

• As thromboprophylaxis in the reproductive-aged woman:
• Prior myocardial infarction
• Well documented prior cerebral thrombosis
• History of Pulmonary Embolism or DVT after completion of anti-coagulation
• As preeclampsia prophylaxis in the pregnant woman:
• History of preeclampsia or gestational hypertension
• Prior delivery of severe IUGR infant
• Chronic hypertension
• Renal disease
• Autoimmune Disease
• Insulin-requiring diabetes
• History of IUFD
• Multiple gestation
• Unexplained recurrent pregnancy losses

Treatment

• Aspirin 75-150 mg PO OD, to be started between 11-14 weeks of gestation until 36 weeks of gestation.