1.1
STI Prevention
Guidelines for Management of Sexually Transmitted Infections, 5th Edition, 2025. Chapter 1, Prevention & Service Integration.
Prevention
Reduce STI exposure risk
- Reduce number of sex partners.
- Avoid high-risk behaviours: anal sex; sex under the influence of alcohol/drugs; genital trauma.
- Promote condoms: emphasise consistent and correct use during all sexual activity (penile-vaginal, oral, anal).
Encourage regular testing
- Most STIs are asymptomatic: Chlamydia (66% of men, 85% of women), Gonorrhoea (50% of men, 65% of women), Syphilis (60–70% of new infections) — all go unnoticed.
- STIs are several hundred times more easily transmitted than HIV.
- Asymptomatic STI patients can transmit to others.
Ensure complete treatment
- Stress completing the full course of prescribed medication to avoid recurrence and antibiotic resistance.
- Complete partner treatment is needed to avert re-infection (ping-pong effect).
- Do not resume condomless sex before all partners have completed STI treatment.
Other interventions
- Promote HPV and hepatitis B vaccination.
- Promote VMMC for all non-circumcised men with an STI, or treated as partners of an STI index patient.
- Offer PrEP for HIV prevention and PEP for recent potential HIV exposure.
- Integrate STI services into HIV and sexual and reproductive health services to improve access and reduce stigma.
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