10.8
ACTIVE TB DRUG SAFETY MONITORING AND MANAGEMENT (aDSM)
National TB Management Guidelines, 2018 Edition. Chapter 10, Programmatic and Clinical Management of Drug-Resistant TB.
Clinical description
Active TB drug safety monitoring and management (aDSM) refers to the active and systematic clinical and laboratory assessment of patients while on DR-TB treatment. aDSM is an integral component of the programmatic management of drug-resistant TB (PMDT). Its rationale is based on recent developments in DR-TB treatment, particularly the approval for use of new medicines ahead of the completion of Phase III trials, increased use of repurposed drugs for XDR-TB treatment, and the development of novel second-line regimens. Such approaches need careful monitoring for drug-related harms, some of which may not have been described as yet.
National Tuberculosis Control Programme 123
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