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8.6.1

Immune reconstitution inflammatory syndrome

National TB Management Guidelines, 2018 Edition. Chapter 8, TB and HIV.

Clinical description

  • An HIV-positive patient’s condition could worsen within the first 6 months of starting

ART because of IRIS. IRIS is a result of recovery of the body’s immune system.

  • There are two common IRIS scenarios:

o An unmasking of an occult opportunistic infection o A paradoxical symptomatic relapse or worsening of a prior infection that was seemingly diagnosed and treated successfully.

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